Assessment of the Risk of Developing Cardiovascular Disease in Prediabetic and Diabetic Wistar Rats with Insulinaemia, in a Selected Model

Introduction: This examination assessed the risk of developing cardiovascular disease in pre-diabetic and diabetes with insulinaemia in Wistar rats using the HOMA-IR model. The assessment solidified the role of Wistar rats in the evaluation model and took the blood analytes to screen for diabetes.

Methodology: 84 male Wistar rats measuring 175g were isolated into fourteen groups of six animals each and dealt with high fat eating standard and acknowledged with dexamethasone which achieved diabetes. Group 1 animals were given feed and water. Group 2 animals got no treatment. Groups 3-5 were coordinated Glimepiride and Metformin, and Cinnamon independently while Groups 6-14 were administered 100mg/kg, 300mg/kg, and 500mg/kg of Ginger, Aloe Vera, and mix of Ginger and Aloe Vera exclusively. The concentrates were administered orally. Every illustration of blood serum and plasma was explored using Randox and Accubind packs and an autoanalyser to test for various biochemical and hematological limits.

Results: The overall results revealed a colossal differentiation (p≤0.05) in the limits except for that of Na+. The 500mg/kg body weight part of the concentrate was ideal while there was much basic development in the HOMA-IR with potential gains of 0.94±0.04, 2.28±0.17 and 3.25±0.44 for the three sets. HOMA-IR is enticing over other models, as reported by other investigators. This assessment revealed that HOMA-IR works best in the management of diabetes in connection with various models.

Contributions to Knowledge: HOMA-IR works best at predicting and managing DM.

Administration of varying doses of the extracts to the Wistar rats helped in the control by ameliorating the effect of diabetes as seen in the return of some diabetic markers assayed.

This research used Wistar rats in the evaluation of the HOMA-IR model.

This research compared the blood analytes of non-diabetics, pre-diabetics, and diabetics in order to monitor the onset of diabetes and proffer possible solutions to enhance early detection and manage diabetes.