Johri, Parul and Aquadro, Charles F. and Beaumont, Mark and Charlesworth, Brian and Excoffier, Laurent and Eyre-Walker, Adam and Keightley, Peter D. and Lynch, Michael and McVean, Gil and Payseur, Bret A. and Pfeifer, Susanne P. and Stephan, Wolfgang and Jensen, Jeffrey D. (2022) Recommendations for improving statistical inference in population genomics. PLOS Biology, 20 (5). e3001669. ISSN 1545-7885
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Abstract
The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th century, in which the development of theoretical and statistical population genetic insights outpaced the generation of data to which they could be applied, genomic data are now being produced at a far greater rate than they can be meaningfully analyzed and interpreted. With this wealth of data has come a tendency to focus on fitting specific (and often rather idiosyncratic) models to data, at the expense of a careful exploration of the range of possible underlying evolutionary processes. For example, the approach of directly investigating models of adaptive evolution in each newly sequenced population or species often neglects the fact that a thorough characterization of ubiquitous nonadaptive processes is a prerequisite for accurate inference. We here describe the perils of these tendencies, present our consensus views on current best practices in population genomic data analysis, and highlight areas of statistical inference and theory that are in need of further attention. Thereby, we argue for the importance of defining a biologically relevant baseline model tuned to the details of each new analysis, of skepticism and scrutiny in interpreting model fitting results, and of carefully defining addressable hypotheses and underlying uncertainties.
Item Type: | Article |
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Subjects: | ArticleGate > Biological Science |
Depositing User: | APLOS Lib |
Date Deposited: | 14 Jul 2022 03:58 |
Last Modified: | 14 Jul 2022 03:58 |
URI: | http://ebooks.pubstmlibrary.com/id/eprint/272 |