Acute Impact of Cancer Treatment on Head and Neck Cancer Patients: FIT4TREATMENT

Leão, Inês and Garcia, Catarina and Antunes, Pedro and Campolargo, Ana and Dias, Isabel and Coimbra, Edite and Oliveira, Pedro and Zenha, Horácio and Costa, Horácio and Capela, Andreia and Viamonte, Sofia and Alves, Alberto J. and Joaquim, Ana (2022) Acute Impact of Cancer Treatment on Head and Neck Cancer Patients: FIT4TREATMENT. Cancers, 14 (11). p. 2698. ISSN 2072-6694

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Abstract

Head and neck cancer (HNC) treatment’s toxicities impact several health domains. Exercise training (ET) may be beneficial. This prospective observational study (NCT04996147) aimed to analyse the acute impact of HNC curative multimodal treatment on health-related quality of life (HRQoL), nutritional status, physical and cognitive functions, and ET preferences. Eighteen patients with stage III/IV HNC were evaluated at baseline (T0), and 10 patients were evaluated at the end of treatment (T1), 7 of them after radical chemoradiotherapy (rCRT). At T0, the majority referred a good HRQoL on the EORTC QLQ-C30 questionnaire (median score: 70.8), were moderately malnourished or at risk of malnutrition (78%), recognized the benefits of an ET program, and were willing to participate (78%). After rCRT, there was worsening in HRQoL (75 vs. 50 score, p = 0.014), dysphagia severity (Eating Assessment Tool: 7 vs. 31, p = 0.027; Functional Oral Intake Scale: 6 vs. 4, p = 0.041), handgrip strength (dominant: 40.9 vs. 35.8 kgf, p = 0.027; nondominant: 37.2 vs. 33.9 kgf, p = 0.043), and nutritional status (Patient-Generated Subjective Global Assessment: 7 vs. 18, p = 0.028). HNC patients subjected to radical treatment represent a vulnerable population that might benefit from multimodal supportive care strategies including an ET program.

Item Type: Article
Subjects: ArticleGate > Medical Science
Depositing User: APLOS Lib
Date Deposited: 20 Jul 2022 12:03
Last Modified: 20 Jul 2022 12:03
URI: http://ebooks.pubstmlibrary.com/id/eprint/415

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